End of the road: Astrocyte endfeet regulate OPC migration and myelination

Greg J Duncan; Ben Emery

doi:10.1016/j.neuron.2022.12.023

End of the road: Astrocyte endfeet regulate OPC migration and myelination

Neuron. 2023 Jan 18;111(2):139-141. doi: 10.1016/j.neuron.2022.12.023.

Authors

Greg J Duncan¹, Ben Emery²

Affiliations

¹ Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: duncangr@ohsu.edu.
² Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: emeryb@ohsu.edu.

PMID: 36657394
DOI: 10.1016/j.neuron.2022.12.023

Abstract

Oligodendrocyte precursor cells (OPCs) use the vasculature as a scaffold for their migration. In this issue of Neuron, Su et al. determine that astrocytic ensheathment of the vasculature mediates OPC detachment from blood vessels via the secretion of semaphorins, regulating the timing of oligodendrocyte differentiation.

Publication types

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MeSH terms

Astrocytes / physiology
Cell Differentiation / physiology
Neurogenesis
Neurons
Oligodendrocyte Precursor Cells* / physiology
Oligodendroglia* / physiology