Nasal Septal Perforation Secondary to Graft-Versus-Host Disease

Will P Hoover; Caleb P Wilson; Sukaina Hasnie; Kibwei A McKinney

doi:10.1159/000528866

Nasal Septal Perforation Secondary to Graft-Versus-Host Disease

ORL J Otorhinolaryngol Relat Spec. 2023;85(2):109-111. doi: 10.1159/000528866. Epub 2023 Jan 19.

Authors

Will P Hoover¹, Caleb P Wilson², Sukaina Hasnie², Kibwei A McKinney²

Affiliations

¹ Department of Otolaryngology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA, will-hoover@ouhsc.edu.
² Department of Otolaryngology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

PMID: 36657411
DOI: 10.1159/000528866

Abstract

Nasal septal perforation is a full-thickness defect of the nasal septum. There are many described etiologies of nasal septal perforation, including trauma, infectious, neoplastic, iatrogenic, and autoimmune. Graft-versus-host disease (GVHD) is a common and potentially life-threatening complication that can occur after an allogenic transplant. GVHD can result in the development of autoantibodies that lead to granulomatous inflammation with necrotizing vasculitis, causing perforation of the nasal septum. In this report, we describe a patient with nasal septal perforation secondary to GVHD and hope to provide novel insights into the association of GVHD and nasal septal perforation.

Keywords: Graft-versus-host disease; Nasal septal perforation; Rhinology; Vasculitis.

Publication types

Case Reports

MeSH terms

Graft vs Host Disease* / complications
Humans
Nasal Septal Perforation* / etiology
Nasal Septum / surgery