Microbial sensitivity of the common pathogens for UTIs are declining in diabetic patients compared to non-diabetic patients in Bangladesh: An institution-based retrospective study

Manik Chandra Shill; Md Nurul Absar Bin Mohsin; Usha Showdagor; Sharif Nahid Hasan; Md Zahidul Islam Zahid; Sabrin Islam Khan; Murad Hossain; Ghazi Mohammad Sayedur Rahman; Hasan Mahmud Reza

doi:10.1016/j.heliyon.2023.e12897

Microbial sensitivity of the common pathogens for UTIs are declining in diabetic patients compared to non-diabetic patients in Bangladesh: An institution-based retrospective study

Heliyon. 2023 Jan 10;9(1):e12897. doi: 10.1016/j.heliyon.2023.e12897. eCollection 2023 Jan.

Authors

Manik Chandra Shill¹, Md Nurul Absar Bin Mohsin¹, Usha Showdagor¹, Sharif Nahid Hasan¹, Md Zahidul Islam Zahid¹, Sabrin Islam Khan¹, Murad Hossain¹, Ghazi Mohammad Sayedur Rahman¹, Hasan Mahmud Reza¹

Affiliation

¹ Department of Pharmaceutical Sciences, North South University, Bashundhara, Dhaka 1229, Bangladesh.

Abstract

Background: Urinary tract infection (UTI) is one of the most recurrent infections in the community and healthcare settings. Although many studies related with microbial sensitivity (MS) of uropathogens (UPs) to antibiotics have been done in Bangladesh, no conclusive study has compared antibiotic sensitivity (AS) to UPs in diabetic and non-diabetic patients. The aim of the study is to find out whether there is a difference in AS in common UPs between diabetic and non-diabetic UTI patients.

Methods: A retrospective review was conducted on 833 patients. The data was collected from different diagnostic centers located within Dhaka city in Bangladesh, and the data was analyzed using convenient statistical tools.

Results: We have studied a total of 833 UTI patients. Out of 833 patients, 664 were diabetic and 169 were non-diabetic patients respectively. Among the studied population, females were found to be more inclined to have UTIs as compared to males. E. coli was found to be the leading UPs in our study. Patients within the age of 20-34 were more vulnerable to UTI in both groups. Imipenem and meropenem showed 100% sensitivity against E. coli, Staphylococcus and Klebsiella in non-diabetic patients, while both antibiotics showed lower sensitivity to the same organisms in diabetic patients. Antibiotics like nitrofurantoin (p ≤ 0.0002), ceftazidime (p ≤ 0.0124) and ceftriaxone (p ≤ 0.0168) showed less sensitivity to E. coli in diabetic UTI patients as compared to non-diabetic UTI patients. Overall sensitivity patterns elucidated that all the studied antibiotics, except ciprofloxacin and levofloxacin, showed lower sensitivity against UPs in diabetic while compared to non-diabetic UTI patients (p= <0.05 to 0.0001).

Conclusion: We found significant difference in microbial sensitivity in patients with diabetes compared to non-diabetic UTI patients. Diabetes changes the pathophysiological state of the uropathogens leading to the declining sensitivity of the antibiotics in diabetic patients with UTIs.

Keywords: Antibiotic resistance; Diabetes; Urinary tract infections; Uropathogens.