Selective degradation of the p53-R175H oncogenic hotspot mutant by an RNA aptamer-based PROTAC

Clin Transl Med. 2023 Feb;13(2):e1191. doi: 10.1002/ctm2.1191.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aptamers, Nucleotide* / genetics
  • Cell Line, Tumor
  • Mutation / genetics
  • Tumor Suppressor Protein p53* / genetics
  • Tumor Suppressor Protein p53* / metabolism

Substances

  • Tumor Suppressor Protein p53
  • Aptamers, Nucleotide