Photoinduced Decarboxylative C3-H Alkylation of Quinoxalin-2(1 H)-ones

J Org Chem. 2023 Feb 17;88(4):2631-2641. doi: 10.1021/acs.joc.2c02823. Epub 2023 Feb 3.

Abstract

An efficient, catalyst- and additive-free, visible-light-driven radical C3-H alkylation of quinoxalin-2(1H)-one derivatives has been developed. This reaction utilizes alkyl-NHP-esters as an alkyl radical donor and quinoxalin-2(1H)-one derivatives as an alkyl radical acceptor. The operationally simple protocol works under mild reaction conditions and tolerates a variety of functional groups. Furthermore, the synthetic utility of the methodology was successfully implemented for synthesizing biologically relevant C3-alkyl substituted quinoxalin-2(1H)-one derivatives.