It Does Exist! Diagnosis and Management of Thyroid Carcinomas Originating in Struma Ovarii

Abstract

Thyroid carcinoma originating in struma ovarii comprises a small minority of all cases of struma ovarii. Given the rarity of this diagnosis, literature to guide evaluation and management is limited. The most common carcinoma originating from struma ovarii is papillary thyroid carcinoma. Treatment includes surgery, including a fertility sparing approach if disease is confined to the ovary, with consideration of total thyroidectomy and radioactive iodine ablation for high-risk pathologic features or disease spread beyond the ovary. This review discusses the histopathologic findings, molecular pathology, clinical implications and management, and prognosis of thyroid carcinomas originating in struma ovarii.

Keywords: Follicular thyroid carcinoma (FTC); Follicular variant papillary thyroid carcinoma (FVPTC); Highly differentiated follicular carcinoma arising from struma ovarii (HDFCO); Ovary; Papillary thyroid carcinoma (PTC); Struma ovarii; Teratoma.