Neuroscience: Visual restoration with optogenetics

Miranda L Scalabrino; Greg D Field

doi:10.1016/j.cub.2022.12.052

Neuroscience: Visual restoration with optogenetics

Curr Biol. 2023 Feb 6;33(3):R110-R112. doi: 10.1016/j.cub.2022.12.052.

Authors

Miranda L Scalabrino¹, Greg D Field²

Affiliations

¹ Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA 90095, USA.
² Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA 90095, USA. Electronic address: gfield@mednet.ucla.edu.

PMID: 36750022
DOI: 10.1016/j.cub.2022.12.052

Abstract

Treating photoreceptor degenerative diseases is an exciting application of optogenetic technologies. However, there are significant challenges, such as producing normal visual signaling as the retina rewires in response to photoreceptor death. However, a new study shows remarkable functional stability in retinal circuits that can be engaged by optogenetics following photoreceptor loss.

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MeSH terms

Humans
Neurosciences*
Optogenetics
Photoreceptor Cells
Retina
Retinal Degeneration* / therapy