Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn's Disease

Corey A Siegel; Lori S Siegel; Marla C Dubinsky; Stephan Targan; Jonathan Braun; Carol Landers; Janine Bilsborough; Fred Princen; Karen Lasch; Ninfa Candela; Dermot P B McGovern; Thierry Dervieux

doi:10.1093/crocol/otab074

Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn's Disease

Crohns Colitis 360. 2021 Oct 30;3(4):otab074. doi: 10.1093/crocol/otab074. eCollection 2021 Oct.

Authors

Corey A Siegel^{1

2}, Lori S Siegel², Marla C Dubinsky^{2

3}, Stephan Targan⁴, Jonathan Braun⁵, Carol Landers⁴, Janine Bilsborough⁴, Fred Princen⁵, Karen Lasch⁶, Ninfa Candela⁶, Dermot P B McGovern⁴, Thierry Dervieux⁵

Affiliations

¹ Dartmouth-Hitchcock Inflammatory Bowel Disease Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
² MiTest Health, LLC, Hanover, New Hampshire, USA.
³ Susan and Leonard Feinstein Inflammatory Bowel Disease Clinical Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
⁴ F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
⁵ Prometheus Laboratories, Inc., San Diego, California, USA.
⁶ Takeda Pharmaceuticals U.S.A., Inc., Lexington, Massachusetts, USA.

Abstract

Background: Patients with Crohn's disease (CD) are at risk of complications. Performance characteristics of a decision support tool assessing the risk of CD complications were evaluated.

Methods: CDPATH (formerly called the Personalized Risk and Outcome Prediction Tool [PROSPECT]) was calibrated and validated in 2 cohorts. Tool prediction of disease characteristics was assessed using Cox regression and Harrell's C-statistic.

Results: All associations of CD complications and CDPATH components were significant except perianal location. There was a significant association between individualized risk assessment scores and CD complications in both cohorts.

Conclusion: CDPATH is validated as a clinical decision support tool for assessing the risk of CD complications.

Keywords: Crohn’s disease; clinical decision support tool; complications; risk assessment; validation.