Firing up neutrophil anti-tumor immunity with cocktails

Meiyi Li; Melissa Ng; Lai Guan Ng

doi:10.1016/j.ccell.2023.01.005

Firing up neutrophil anti-tumor immunity with cocktails

Cancer Cell. 2023 Feb 13;41(2):227-229. doi: 10.1016/j.ccell.2023.01.005.

Authors

Meiyi Li¹, Melissa Ng², Lai Guan Ng³

Affiliations

¹ Shanghai Immune Therapy Institute, Shanghai Jiao Tong University School of Medicine affiliated Renji Hospital, Shanghai, China.
² Singapore Immunology Network (SIgN), A(∗)STAR (Agency for Science, Technology and Research), Biopolis, Singapore, Singapore.
³ Shanghai Immune Therapy Institute, Shanghai Jiao Tong University School of Medicine affiliated Renji Hospital, Shanghai, China; Singapore Immunology Network (SIgN), A(∗)STAR (Agency for Science, Technology and Research), Biopolis, Singapore, Singapore. Electronic address: nglaiguan@renji.com.

PMID: 36787693
DOI: 10.1016/j.ccell.2023.01.005

Abstract

Neutrophils constitute a considerable proportion of all leukocytes found in tumors and are essential for promoting tumor growth. In this issue, Linde et al. demonstrate that an antibody cocktail therapy consisting of tumor necrosis factor (TNF), anti-CD40 monoclonal antibody, and tumor-binding antibody can boost the anti-tumor activity of neutrophils.

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MeSH terms

Antibodies, Monoclonal* / pharmacology
Antibodies, Monoclonal* / therapeutic use
Humans
Neutrophils*
Tumor Necrosis Factor-alpha

Substances

Antibodies, Monoclonal
Tumor Necrosis Factor-alpha