Cancer cachexia: involvement of an expanding macroenvironment

Benjamin R Pryce; David J Wang; Teresa A Zimmers; Michael C Ostrowski; Denis C Guttridge

doi:10.1016/j.ccell.2023.02.007

Cancer cachexia: involvement of an expanding macroenvironment

Cancer Cell. 2023 Mar 13;41(3):581-584. doi: 10.1016/j.ccell.2023.02.007. Epub 2023 Mar 2.

Authors

Benjamin R Pryce¹, David J Wang¹, Teresa A Zimmers², Michael C Ostrowski³, Denis C Guttridge⁴

Affiliations

¹ Department of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA.
² Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Melvin and Bren Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA.
³ Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
⁴ Department of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: guttridg@musc.edu.

Abstract

Advanced cancers often present with the cachexia syndrome that impacts peripheral tissues, leading to involuntary weight loss and reduced prognosis. The central tissues undergoing depletion are skeletal muscle and adipose, but recent findings reveal an expanding tumor macroenvironment involving organ crosstalks that underlie the cachectic state.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural

MeSH terms

Cachexia* / etiology
Cachexia* / pathology
Humans
Muscle, Skeletal
Neoplasms* / complications
Neoplasms* / pathology
Prognosis

Abstract

Publication types

MeSH terms

Grants and funding