Serum NT-ProBNP potential marker of cirrhotic cardiomyopathy

Folia Med (Plovdiv). 2022 Oct 31;64(5):740-745. doi: 10.3897/folmed.64.e65824.

Abstract

Based on many previous studies, liver cirrhosis is traditionally associated with cardiac dysfunction. The main clinical features of cirrhotic cardiomyopathy include attenuated systolic contractility in response to physiologic or pharmacologic strain, diastolic dysfunction, electrical conductance abnormalities, and chronotropic incompetence. Previous studies have found that the levels of brain natriuretic peptide (BNP) and its precursor the N-terminal pro B-type natriuretic peptide (NT-proBNP) are elevated in cirrhosis with systolic as well as diastolic dysfunction.

Keywords: cirrhotic cardiomyopathy diastolic dysfunction liver cirrhosis portal hypertension prolonged QTc.

MeSH terms

  • Cardiomyopathies*
  • Humans
  • Liver Cirrhosis
  • Natriuretic Peptide, Brain*
  • Peptide Fragments

Substances

  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain
  • Peptide Fragments