Analysis and evaluation of correlation between DNA polymorphism in the genes MTHFR, PAI-1 and serum creatinine, creatinine clearance and albumin/creatinine ratio in morning urine of patients with type 2 diabetes mellitus and diabetic nephropathy

Folia Med (Plovdiv). 2022 Dec 31;64(6):896-904. doi: 10.3897/folmed.64.e67912.

Abstract

Diabetic nephropathy is a major microangiopathic complication of type 2 diabetes and a leading cause of chronic kidney disease (CKD).

Keywords: creatinine clearance and albumin/creatinine ratio diabetic nephropathy polymorphism C677T MTHFR polymorphism 4G/5G for PAI-1 serum creatinine.

MeSH terms

  • Albumins
  • Creatinine
  • DNA
  • Diabetes Mellitus, Type 2*
  • Diabetic Nephropathies*
  • Humans
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Plasminogen Activator Inhibitor 1

Substances

  • Creatinine
  • Plasminogen Activator Inhibitor 1
  • DNA
  • Albumins
  • MTHFR protein, human
  • Methylenetetrahydrofolate Reductase (NADPH2)