Selectivity in Cationic Cyclizations Involving Alkynes: A Computational Study on the Biomimetic Synthesis of Steroids

Abel de Cózar; Ana Arrieta; Fernando P Cossío

doi:10.1002/chem.202300666

Selectivity in Cationic Cyclizations Involving Alkynes: A Computational Study on the Biomimetic Synthesis of Steroids

Chemistry. 2023 Apr 3;29(19):e202300666. doi: 10.1002/chem.202300666. Epub 2023 Mar 13.

Authors

Abel de Cózar^{1

2}, Ana Arrieta¹, Fernando P Cossío¹

Affiliations

¹ Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Centro de Innovación y Química Avanzada (ORFEO-CINQA), and Donostia International Physics Center (DIPC), P. K. 1072, 20018, San Sebastián-Donostia, Spain.
² Ikerbasque, Basque Foundation for Science, 48009, Bilbao, Spain.

PMID: 36912735
DOI: 10.1002/chem.202300666

Abstract

Invited for the cover of this issue are Abel de Cózar, Ana Arrieta and Fernando P. Cossío at the University of the Basque Country. The image depicts the evolution of a reactive cation to the corresponding cyclic intermediate in the course of a regio- and stereocontrolled biomimetic cyclization. Read the full text of the article at 10.1002/chem.202204028.