Regulation of CD8 T cell by B-cells: A narrative review

Front Immunol. 2023 Mar 8:14:1125605. doi: 10.3389/fimmu.2023.1125605. eCollection 2023.

Abstract

Activation of CD4 T cells by B cells has been extensively studied, but B cell-regulated priming, proliferation, and survival of CD8 T cells remains controversial. B cells express high levels of MHC class I molecules and can potentially act as antigen-presenting cells (APCs) for CD8 T cells. Several in vivo studies in mice and humans demonstrate the role of B cells as modulators of CD8 T cell function in the context of viral infections, autoimmune diseases, cancer and allograft rejection. In addition, B-cell depletion therapies can lead to impaired CD8 T-cell responses. In this review, we attempt to answer 2 important questions: 1. the role of B cell antigen presentation and cytokine production in the regulation of CD8 T cell survival and cell fate determination, and 2. The role of B cells in the formation and maintenance of CD8 T cell memory.

Keywords: B cell; CD8 lymphocytes +; auto-immune; crosstalk; regulation.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigen Presentation
  • Antigen-Presenting Cells
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes*
  • Humans
  • Lymphocyte Activation*
  • Mice

Grants and funding

This work was supported by the LabEx IGO program (n° ANR-11-LABX-0016) funded by the «Investment into the Future» French Government program, managed by the National Research Agency (ANR)". This work was also supported by grants from the ABM, SFNDT, Association France Vascularite, CHU de Nantes, ANR (ANR-10-IBHU-005, 17-RHUS-0010), ESOT, FRS-FNRS (40010386) and the ERA PerMed AGORA (ERAPERMED2021-086).