High density of FOXP3 predicts better prognosis in germinal and non-germinal centre diffuse large B-cell lymphoma

Asmaa M Ahmed; Sally S Abdel-Hakeem; Maged A F Amine; Etemad H Yassin; Fatma A M Badary

doi:10.1111/iep.12477

High density of FOXP3 predicts better prognosis in germinal and non-germinal centre diffuse large B-cell lymphoma

Int J Exp Pathol. 2023 Jun;104(3):128-139. doi: 10.1111/iep.12477. Epub 2023 Mar 28.

Authors

Asmaa M Ahmed¹, Sally S Abdel-Hakeem², Maged A F Amine³, Etemad H Yassin¹, Fatma A M Badary¹

Affiliations

¹ Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
² Department of Oncologic Pathology, South Egypt Cancer Institute, Faculty of Medicine, Assiut University, Assiut, Egypt.
³ Medical Oncology Department, South Egypt Cancer Institute, Faculty of Medicine, Assiut University, Assiut, Egypt.

Abstract

This study highlights the prognostic impact of FOXP3 and CD68 expression in DLBCL, NOS and in its GCB and non-GCB subtypes. This may help the development of individualized therapy, prognostic prediction and therapy stratification.

Keywords: CD68; DLBCL lymphoma; FOXP3; GCB.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Forkhead Transcription Factors / metabolism
Germinal Center* / metabolism
Germinal Center* / pathology
Humans
Lymphoma, Large B-Cell, Diffuse* / diagnosis
Lymphoma, Large B-Cell, Diffuse* / pathology
Prognosis

Substances

Forkhead Transcription Factors
FOXP3 protein, human