A special issue of Essays in Biochemistry on structural mass spectrometry

Hannah M Britt; Rebecca Beveridge; Antonio N Calabrese

doi:10.1042/EBC20230006

A special issue of Essays in Biochemistry on structural mass spectrometry

Essays Biochem. 2023 Mar 29;67(2):147-149. doi: 10.1042/EBC20230006.

Authors

Hannah M Britt^{1

2}, Rebecca Beveridge³, Antonio N Calabrese⁴

Affiliations

¹ Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3QZ, U.K.
² The Kavli Institute for Nanoscience Discovery, Sherrington Road, Oxford OX1 3QU, U.K.
³ Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, U.K.
⁴ Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K.

Abstract

Mass spectrometry (MS) is now established as an analytical tool to interrogate the structure and dynamics of proteins and their assemblies. An array of MS-based technologies has been developed, with each providing unique information pertaining to protein structure, and forming the heart of integrative structural biology studies. This special issue includes a collection of review articles that discuss both established and emerging structural MS methodologies, along with examples of how these technologies are being deployed to interrogate protein structure and function. Combined, this collection highlights the immense potential of the structural MS toolkit in the study of molecular mechanisms underpinning cellular homeostasis and disease.

Keywords: biochemical techniques and resources; mass spectrometry; structural biology.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biochemistry* / methods
Mass Spectrometry / methods
Molecular Biology
Proteins* / chemistry

Substances

Proteins

Grants and funding

MR/T020970/1/MRC_/Medical Research Council/United Kingdom