New diterpenoids and phenolic amides from Icacina mannii Oliv

Abstract

Fourteen undescribed compounds including five neoclerodanes (1-5), three labdanes (12-14), three pimarane (15-17) derivatives, one carbamate (24) and two clovamide-type amides (25 and 26), along with twenty-two known compounds (6-11, 18-23 and 27-36) were isolated from the tuber and stem of Icacina mannii. Their structures were elucidated by 1D and 2D NMR and HR-ESI-MS data analysis, and by comparing their NMR data with those of the literature.

Keywords: Clovamide; Diterpenoids; Icacina mannii; Icacinaceae; Labdane; Neoclerodane; Pimarane.