1 Department of Medicine 2, Hematology and Oncology, Goethe University, 60590 Frankfurt, Germany; Frankfurt Cancer Institute, Goethe University, 60590 Frankfurt, Germany; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: g.bug@em.uni-frankfurt.de.