β2ARs: double edge sword in heart function

Heather K Beasley; Celestine N Wanjalla; Annet Kirabo; Antentor Hinton Jr

doi:10.1016/j.molmed.2023.03.003

β₂ARs: double edge sword in heart function

Trends Mol Med. 2023 Jun;29(6):422-424. doi: 10.1016/j.molmed.2023.03.003. Epub 2023 Mar 27.

Authors

Heather K Beasley¹, Celestine N Wanjalla², Annet Kirabo³, Antentor Hinton Jr⁴

Affiliations

¹ Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
² Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA.
³ Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
⁴ Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA. Electronic address: antentor.o.hinton.jr@Vanderbilt.Edu.

Abstract

Deng and colleagues highlight the importance of understanding the divergent roles of β2-adrenoceptor (β₂AR) in high-fat diet-induced heart failure. β₂AR signaling has beneficial and detrimental effects depending on the context and level of activation. We discuss the importance of these findings and their implications in developing effective and safe therapies.

Keywords: HFD; heart failure; myocyte; myofibroblast; β2 adrenoceptor.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Heart Failure* / therapy
Humans
Receptors, Adrenergic, beta-2* / physiology
Signal Transduction

Substances

Receptors, Adrenergic, beta-2

Abstract

Publication types

MeSH terms

Substances

Grants and funding