Antimicrobial Resistance and Biofilm Formation of Staphylococcus aureus Isolates from Febrile Cases: Findings from a Rural Cohort of Odisha, India

Pol J Microbiol. 2023 Jun 14;72(2):209-214. doi: 10.33073/pjm-2023-005. eCollection 2023 Jun 1.

Abstract

This study investigated the major pathogens in fever patients' blood in a rural cohort and characterized its virulence. A total of 718 blood samples received from IPD/OPD (inpatient department/outpatient department) patients with H/O (history of) fever were cultured, and 73 out of 83 culture-positive samples were identified as Staphylococcus aureus. The isolates showed higher resistance to penicillin, most being multidrug resistant. They formed biofilm in vitro, and 27.4% of the isolates were strong biofilm producers. They were sensitive towards linezolid, gentamicin, and tetracycline. The findings emphasize the necessity of preventing and managing staphylococcal infection and regular antimicrobial surveillance in rural areas.

Keywords: S. aureus; biofilm; febrile cases; resistance; rural area.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Biofilms
  • Drug Resistance, Bacterial
  • Humans
  • Methicillin-Resistant Staphylococcus aureus*
  • Microbial Sensitivity Tests
  • Staphylococcal Infections* / epidemiology
  • Staphylococcus aureus

Substances

  • Anti-Bacterial Agents

Grants and funding

Funding The study was supported by funding received from the Indian Council of Medical Research (No. VIR/28/2019/ECD-I).