The role of tumor-derived extracellular vesicles containing noncoding RNAs in mediating immune cell function and its implications from bench to bedside

Chen-Guang Liu; Jun Chen; Robby Miguel Wen-Jing Goh; Yu-Xuan Liu; Lingzhi Wang; Zhaowu Ma

doi:10.1016/j.phrs.2023.106756

The role of tumor-derived extracellular vesicles containing noncoding RNAs in mediating immune cell function and its implications from bench to bedside

Pharmacol Res. 2023 May:191:106756. doi: 10.1016/j.phrs.2023.106756. Epub 2023 Apr 3.

Authors

Chen-Guang Liu¹, Jun Chen², Robby Miguel Wen-Jing Goh³, Yu-Xuan Liu⁴, Lingzhi Wang⁵, Zhaowu Ma⁶

Affiliations

¹ School of Basic Medicine, Health Science Center, Yangtze University, 1 Nanhuan Road, Jingzhou, Hubei 434023, China; Department of Oncology, The Second Hospital of Dalian Medical University, Dalian 116021, China.
² Department of Oncology, The Second Hospital of Dalian Medical University, Dalian 116021, China.
³ Watford General Hospital, Vicarage Road Watford Herts, WD18 0HB, UK.
⁴ Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore.
⁵ Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore; Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore; National University Cancer Institute, National University of Singapore, 119074, Singapore; NUS Centre for Cancer Research (N2CR), National University of Singapore, 117599, Singapore. Electronic address: csiwl@nus.edu.sg.
⁶ School of Basic Medicine, Health Science Center, Yangtze University, 1 Nanhuan Road, Jingzhou, Hubei 434023, China. Electronic address: mazw@yangtzeu.edu.cn.

PMID: 37019192
DOI: 10.1016/j.phrs.2023.106756

Abstract

Extracellular vesicles (EVs) are membrane-encapsulated vesicles released by almost all cell types, which participate in intercellular communication by delivering different types of molecular cargoes, such as non-coding RNAs (ncRNAs). Accumulating evidence suggests that tumor-derived EVs act as a bridge for intercellular crosstalk between tumor cells and surrounding cells, including immune cells. Tumor-derived EVs containing ncRNAs (TEV-ncRNAs) mediate intercellular crosstalk to manipulate immune responses and affect the malignant phenotypes of cancer cells. In this review, we summarize the double-edged roles and the underlying mechanisms of TEV-ncRNAs in regulating innate and adaptive immune cells. We also highlight the advantages of using TEV-ncRNAs in liquid biopsies for cancer diagnosis and prognosis. Moreover, we outline the use of engineered EVs to deliver ncRNAs and other therapeutic agents for cancer therapy.

Keywords: Cancer therapy; Extracellular vesicles; Non-coding RNAs; Tumor immunity.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Communication
Extracellular Vesicles* / metabolism
Immunity, Innate
RNA, Untranslated / genetics
RNA, Untranslated / metabolism

Substances

RNA, Untranslated