Impact of Monkeypox Virus Infection on Immune Parameters in a Woman With Human Immunodeficiency Virus Receiving Clinically Effective Antiretroviral Therapy

J Infect Dis. 2023 Aug 11;228(3):270-275. doi: 10.1093/infdis/jiad096.

Abstract

We describe the immunologic and virologic impact of monkeypox (mpox) infection in a woman with human immunodeficiency virus (HIV) whose plasma HIV viremia was suppressed by clinically effective antiretroviral therapy. Extensive phenotypic analyses of B and T cells in peripheral blood and biomarkers in plasma showed significant immunologic perturbations despite the presence of mild mpox disease. Dramatic shifts were noted in the frequencies of total B cells, plasmablasts, and plasmablast immunoglobulin isotypes. Flow cytometric analyses showed a dramatic increase in the frequency of CD38+HLA-DR+ CD8+ T cells after mpox infection. Our data offer guidance for future studies involving mpox infection in affected populations.

Keywords: B cells; HIV; T cells; monkeypox; ‌Biomarkers.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • CD8-Positive T-Lymphocytes
  • Female
  • HIV Infections* / complications
  • HIV Infections* / drug therapy
  • HIV-1*
  • Humans
  • Monkeypox virus
  • Mpox (monkeypox)* / drug therapy