The neuroendocrine carcinoma component of gastric mixed adenoneuroendocrine carcinoma could develop with MLH1 deficiency independent of TP53 mutation

Pathol Int. 2023 Jun;73(6):261-263. doi: 10.1111/pin.13324. Epub 2023 Apr 17.

Authors

Rei Hashimoto¹, Keisuke Matsusaka¹, Tomoaki Matsumura², Koichi Hayano³, Naoya Kato², Hisahiro Matsubara³, Jun-Ichiro Ikeda^{1

4}

Affiliations

¹ Department of Pathology, Chiba University Hospital, Chiba, Japan.
² Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
³ Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
⁴ Department of Diagnostic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan.

PMID: 37067391
DOI: 10.1111/pin.13324

No abstract available

Keywords: Instability; MLH1 deficiency; TP53 mutation; gastric MANEC; gastric adenocarcinoma; microsatellite; neuroendocrine carcinoma.

Publication types

Letter

MeSH terms

Adenocarcinoma* / pathology
Carcinoma, Neuroendocrine* / genetics
Carcinoma, Neuroendocrine* / pathology
Humans
MutL Protein Homolog 1 / genetics
Mutation
Stomach Neoplasms* / genetics
Stomach Neoplasms* / pathology
Tumor Suppressor Protein p53 / genetics

Substances

TP53 protein, human
Tumor Suppressor Protein p53
MLH1 protein, human
MutL Protein Homolog 1

Supplementary concepts

Adenocarcinoid tumor