Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai

Jiarui Zhang; Huixue Ma; Shuangshuang Jin; Xuehuan Liu; Lei Li; Zhaonan Liu; Guoqiang Li; Pinglin Li

doi:10.3390/md21040223

Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai

Mar Drugs. 2023 Mar 30;21(4):223. doi: 10.3390/md21040223.

Authors

Jiarui Zhang^{1

2}, Huixue Ma^{1

2}, Shuangshuang Jin^{1

2}, Xuehuan Liu^{1

2}, Lei Li³, Zhaonan Liu^{1

2}, Guoqiang Li^{1

2}, Pinglin Li^{1

2}

Affiliations

¹ Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
² Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao 266235, China.
³ Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.

Abstract

Seven new lobane diterpenoids, namely, lobocatalens A-G (1-7), were isolated from the Xisha soft coral Lobophytum catalai. Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with the literature data, QM-MNR, and TDDFT-ECD calculations. Among them, lobocatalen A (1) is a new lobane diterpenoid with an unusual ether linkage between C-14 and C-18. In addition, compound 7 showed moderate anti-inflammatory activity in the zebrafish models and cytotoxic activity against the K562 human cancer cell line.

Keywords: Lobophytum catalai; anti-inflammatory activity; cytotoxic activity; lobane diterpenoids; lobocatalens A–G.

MeSH terms

Animals
Anthozoa* / chemistry
Anti-Inflammatory Agents / chemistry
Antineoplastic Agents* / pharmacology
Diterpenes* / chemistry
Diterpenes* / pharmacology
Humans
Molecular Structure
Zebrafish

Substances

Anti-Inflammatory Agents
Antineoplastic Agents
Diterpenes

Abstract

MeSH terms

Substances

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