Are fewer cases of diabetes mellitus diagnosed in the months after SARS-CoV-2 infection? A population-level view in the EHR-based RECOVER program

Neha V Reddy; Hsin-Chieh Yeh; Jena S Tronieri; Til Stürmer; John B Buse; Jane E Reusch; Steven G Johnson; Rachel Wong; Richard Moffitt; Kenneth J Wilkins; Jeremy Harper; Carolyn T Bramante; N3C and RECOVER Consortiums

doi:10.1017/cts.2023.34

Are fewer cases of diabetes mellitus diagnosed in the months after SARS-CoV-2 infection? A population-level view in the EHR-based RECOVER program

J Clin Transl Sci. 2023 Mar 8;7(1):e90. doi: 10.1017/cts.2023.34. eCollection 2023.

Authors

Affiliations

¹ Division of General Internal Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
² Departments of Medicine, Epidemiology and Oncology, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA.
³ Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
⁴ Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁵ Division of Endocrinology, Department of Medicine, University of North Carolina Medical School, Chapel Hill, NC, USA.
⁶ University of Colorado Denver Anschutz Medical Campus, Denver, CO, USA.
⁷ Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA.
⁸ Department of Biomedical Informatics, Stony Brook University, Stony Brook, NY, USA.
⁹ Biostatistics Program, Office of the Director, National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, MD, USA.
¹⁰ Owl HealthWorks, Indianapolis, IN, USA.

^# Contributed equally.

Abstract

Long-term sequelae of severe acute respiratory coronavirus-2 (SARS-CoV-2) infection may include increased incidence of diabetes. Here we describe the temporal relationship between new type 2 diabetes and SARS-CoV-2 infection in a nationwide database. We found that while the proportion of newly diagnosed type 2 diabetes increased during the acute period of SARS-CoV-2 infection, the mean proportion of new diabetes cases in the 6 months post-infection was about 83% lower than the 6 months preinfection. These results underscore the need for further investigation to understand the timing of new diabetes after COVID-19, etiology, screening, and treatment strategies.

Keywords: COVID-19; PASC; epidemiology; new diabetes; type 2 diabetes.

Abstract

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