Tails don't tell the whole story

Structure. 2023 May 4;31(5):505-506. doi: 10.1016/j.str.2023.03.015.

Abstract

Before engaging G protein-coupled receptors (GPCRs) to transduce extracellular signals, heterotrimeric G proteins (Gαβγ) must fold properly with the help of chaperones. In this issue of Structure, Papasergi-Scott et al. (2023) unveil the molecular basis for how mammalian Ric-8 chaperones achieve selectivity for their respective Gα subunit clients.

Publication types

  • Comment

MeSH terms

  • Animals
  • Guanine Nucleotide Exchange Factors* / metabolism
  • Humans
  • Mammals / metabolism
  • Molecular Chaperones / metabolism
  • Receptors, G-Protein-Coupled* / metabolism

Substances

  • Guanine Nucleotide Exchange Factors
  • Receptors, G-Protein-Coupled
  • Molecular Chaperones