"Appraisal of state-of-the-art" The 2021 Distinguished Service Award of the Safety Pharmacology Society: Reflecting on the past to tackle challenges ahead

J Pharmacol Toxicol Methods. 2023 Sep-Oct:123:107269. doi: 10.1016/j.vascn.2023.107269. Epub 2023 May 5.

Abstract

This appraisal of state-of-the-art manuscript highlights and expands upon the thoughts conveyed in the lecture of Dr. Jean-Pierre Valentin, recipient of the 2021 Distinguished Service Award of the Safety Pharmacology Society, given on the 2nd December 2021. The article reflects on the strengths, weaknesses, opportunities, and threats that surrounded the evolution of safety and secondary pharmacology over the last 3 decades with a particular emphasis on pharmaceutical drug development delivery, scientific and technological innovation, complexities of regulatory framework and people leadership and development. The article further built on learnings from past experiences to tackle constantly emerging issues and evolving landscape whilst being cognizant of the challenges facing these disciplines in the broader drug development and societal context.

Keywords: Core battery studies; Distinguished Service Award; Follow-up studies; Hazard identification; Human risk assessment; Pharmaceutical drug development; Regulatory guidance; Risk management and mitigation; Safety pharmacology; Supplemental studies.

MeSH terms

  • Awards and Prizes*
  • Drug Evaluation, Preclinical
  • Drug-Related Side Effects and Adverse Reactions*
  • Humans
  • Pharmaceutical Preparations
  • Pharmacology*
  • Societies

Substances

  • Pharmaceutical Preparations