Decoding nociceptor-DC dialogues

Theo Crosson; Sebastien Talbot

doi:10.1016/j.immuni.2023.04.016

Decoding nociceptor-DC dialogues

Immunity. 2023 May 9;56(5):906-908. doi: 10.1016/j.immuni.2023.04.016.

Authors

Theo Crosson¹, Sebastien Talbot²

Affiliations

¹ Department of Pharmacology and Physiology, Université de Montréal, Montreal, QC, Canada.
² Department of Pharmacology and Physiology, Karolinska Institutet, Solna, Sweden; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. Electronic address: sebastien.talbot@queensu.ca.

PMID: 37163991
DOI: 10.1016/j.immuni.2023.04.016

Abstract

Neuro-immune interactions link physiological and immune responses in host defense. Hanč et al.¹ report that nociceptors attract dendritic cells (DCs) via the chemokine (C-C motif) ligand 2 (CCL2), initiate a "sentinel" DC program via the neuropeptide calcitonin gene-related peptide (CGRP), and enhance DC inflammatory responses through direct connections. These neuroimmune units integrate nociceptors' rapid responsiveness with DCs' immune coordination, functioning as an advanced warning system.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Calcitonin Gene-Related Peptide*
Dendritic Cells
Nociceptors* / physiology

Substances

Calcitonin Gene-Related Peptide

Abstract

Publication types

MeSH terms

Substances

Grants and funding