Assessment of quality of life (QOL) is one of the key criteria for evaluating the effectiveness of treatment in clinical trials. It is very important to pay attention to the methods of evaluation and analysis. Health-related quality of life is very important in evaluating drug efficacy. The assessment of this indicator in clinical trials is considered as an additional indicator of drug efficacy, a new tool for choosing an effective drug for clinical practice, etc. To assess the quality of life of patients with chronic rhinosinusitis and select an effective drug such as "Gutanos" (anti-inflammatory, antimicrobial nasal drops of plant origin), we followed the recommended steps for cultural adaptation of SNOT-22 into Armenian, creating a tool for assessing patients with clinically significant sinonasal disorders. (rhinosinusitis), as well as for scientific research (Cronbach index = 0.81), the reliability of the test-retest was determined (ICC = 0.85). We found that SNOT-22 is reliable, easy to use, and can be used to facilitate daily clinical practice to highlight the impact of chronic rhinosinusitis on patients' quality of life.