Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres

Wout J Claassen; Coen A C Ottenheijm

doi:10.1085/jgp.202213292

Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres

J Gen Physiol. 2023 Jul 3;155(7):e202213292. doi: 10.1085/jgp.202213292. Epub 2023 May 16.

Authors

Wout J Claassen¹, Coen A C Ottenheijm^{1

2}

Affiliations

¹ Department of Physiology, Amsterdam UMC location, VU Medisch Centrum, Amsterdam, Netherlands.
² Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA.

Abstract

Recent papers by Nelson et al. and Pilagov et al. provide important new information on the ever-expanding role of myosin heads in the regulation of contraction.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cues*
Heart
Muscle, Skeletal / physiology
Myosins
Sarcomeres*

Substances

Myosins

Grants and funding

R01 HL121500/HL/NHLBI NIH HHS/United States