Not just protons: Chloride also activates lysosomal acidic hydrolases

Xinghua Feng; Siyu Liu; Haoxing Xu

doi:10.1083/jcb.202305007

Not just protons: Chloride also activates lysosomal acidic hydrolases

J Cell Biol. 2023 Jun 5;222(6):e202305007. doi: 10.1083/jcb.202305007. Epub 2023 May 16.

Authors

Xinghua Feng^{1

2}, Siyu Liu^{2

3}, Haoxing Xu^{1

2

4}

Affiliations

¹ Department of Neurology and Department of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
² Liangzhu Laboratory and School of Basic Medical Sciences, Zhejiang University, Hangzhou, China.
³ International School of Medicine, Zhejiang University , Yiwu, China.
⁴ Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.

Abstract

Lysosomal hydrolases require an acidic lumen for their optimal activities. In this issue, two independent groups (Wu et al. 2023. J. Cell Biol.https://doi.org/10.1083/jcb.202208155; Zhang et al. 2023. J. Cell. Biol.https://doi.org/10.1083/jcb.202210063) report that hydrolase activation also requires high intralysosomal Cl-, which is established by the lysosomal Cl-/H+ exchanger ClC-7.

Publication types

Comment

MeSH terms

Chloride Channels* / metabolism
Chlorides*
Hydrolases* / metabolism
Lysosomes* / enzymology

Substances

Chlorides
Hydrolases
Chloride Channels