Tracing the genetic fingerprints of tumour evolution: The pursuit of identifying mutations with differential weights within the overall tumour mutation burden and their role in therapeutic responses with immune checkpoint blockade

Clin Transl Med. 2023 Jun;13(6):e1287. doi: 10.1002/ctm2.1287.

Authors

Noushin Niknafs¹, Michael Conroy¹, Valsamo Anagnostou^{1

2}

Affiliations

¹ The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
² The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor
Humans
Immune Checkpoint Inhibitors* / pharmacology
Immune Checkpoint Inhibitors* / therapeutic use
Mutation / genetics
Neoplasms* / drug therapy
Neoplasms* / genetics

Substances

Immune Checkpoint Inhibitors
Biomarkers, Tumor