Histidine-DNA nanoarchitecture as laccase mimetic DNAzymes

Nanoscale. 2023 Jun 30;15(25):10749-10754. doi: 10.1039/d3nr01625k.

Abstract

Herein, we report on the construction of Cu-histidine (His)-DNA hybrids as laccase-mimetic DNAzymes. Cu-His-DNAzymes showed remarkable activity in a colorimetric oxidation reaction between 2,4-dichlorophenol and 4-aminoantipyrine. Our results provide new insights for the systematic construction of tailor-made active sites for biomimetics.

MeSH terms

  • Biomimetics
  • Copper / chemistry
  • DNA / chemistry
  • DNA, Catalytic* / chemistry
  • Histidine / chemistry
  • Laccase / chemistry

Substances

  • DNA, Catalytic
  • Histidine
  • Laccase
  • DNA
  • Copper