We studied therapeutic efficacy and migration characteristics of mesenchymal stem cells isolated from the human placenta after their intracerebral (stereotactic) administration to rats with the experimental ischemic stroke. It was shown that cell therapy significantly improved animal survival rate and reduced the severity of neurological deficit. New data on the migration pathways of transplanted cells in the brain were obtained.
Keywords: cell therapy; intracerebral administration; ischemic stroke; mesenchymal stem cells; middle cerebral artery occlusion model.
© 2023. Springer Science+Business Media, LLC, part of Springer Nature.