Shedding light on stem cells: Optogenetics uncover the role of ERK dynamics in pluripotency

Adam A Moverley; Nicolas Plachta

doi:10.1016/j.devcel.2023.05.016

Shedding light on stem cells: Optogenetics uncover the role of ERK dynamics in pluripotency

Dev Cell. 2023 Jun 19;58(12):1005-1006. doi: 10.1016/j.devcel.2023.05.016.

Authors

Adam A Moverley¹, Nicolas Plachta²

Affiliations

¹ Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; University College London, WC1E 6BT London, UK.
² Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: nicolas.plachta@pennmedicine.upenn.edu.

PMID: 37339602
DOI: 10.1016/j.devcel.2023.05.016

Abstract

In this issue of Developmental Cell, Arekatla et al. use optogenetic technologies to dissect the roles of ERK and AKT dynamics in pluripotency. They show how mouse embryonic stem cells can retain memory of signaling events controlling their fate.

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MeSH terms

Animals
Cell Differentiation
Mice
Mouse Embryonic Stem Cells
Optogenetics*
Signal Transduction*