The human embryo selection arena is associated with transposable element activity

Anna Osnato; Vincent Pasque; Laurent David

doi:10.1371/journal.pbio.3002153

The human embryo selection arena is associated with transposable element activity

PLoS Biol. 2023 Jun 20;21(6):e3002153. doi: 10.1371/journal.pbio.3002153. eCollection 2023 Jun.

Authors

Anna Osnato^{1

2}, Vincent Pasque^{1

2}, Laurent David^{3

4}

Affiliations

¹ KU Leuven-University of Leuven, Department of Development and Regeneration, Leuven Stem Cell Institute, Leuven, Belgium.
² KU Leuven Institute for Single Cell Omics (LISCO), Leuven, Belgium.
³ Nantes Université, Inserm, CR2TI, Nantes, France.
⁴ Nantes Université, CHU Nantes, CNRS, Inserm, BioCore, Nantes, France.

Abstract

Our current understanding of early human development is limited. A study in PLOS Biology found a previously undefined group of cells that diverges from the main lineages and undergo apoptosis through the activity of young transposable elements.

Copyright: © 2023 Osnato et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Publication types

Comment

MeSH terms

Blastocyst*
DNA Transposable Elements* / genetics
Embryo, Mammalian
Humans

Substances

DNA Transposable Elements

Grants and funding

Research in the Pasque lab is funded by The Research Foundation–Flanders (FWO; Odysseus Return Grant G0F7716N to V.P.; FWO grants G0C9320N and G0B4420N to V.P.; EOS project PANDAROME G0I7822N) and the KU Leuven Research Fund (C1 grant C14/21/19 to V.P.) and FWO fellowships. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.