Etiology and Multi-Drug Resistant Profile of Bacterial Infections in Severe Burn Patients, Romania 2018-2022

Medicina (Kaunas). 2023 Jun 14;59(6):1143. doi: 10.3390/medicina59061143.

Abstract

Infections in severe burns and their etiology are and will remain a big concern for the medical field. The multi-drug resistant strains of bacteria are a challenge of today's medicine. The aim of our study was to identify the etiological spectrum of bacterial infections in severe burn patients in Romania and their multi-drug resistant patterns. We performed a prospective study that included 202 adult patients admitted to the intensive care unit (ICU) of the Clinical Emergency Hospital of Plastic, Reconstructive Surgery and Burns, Bucharest, Romania (CEHPRSB), from 1 October 2018 to 1 April 2022, a period which includes the first 2 years of the outbreak of COVID-19. From each patient, wound swabs, endotracheal aspirates, blood for blood culture, and urine were collected. The most frequently isolated bacterium was Pseudomonas aeruginosa (39%), followed by Staphylococcus aureus (12%), Klebsiella spp. (11%), and Acinetobacter baumannii (9%). More than 90% of Pseudomonas aeruginosa and Acinetobacter baumannii were MDR, regardless of the clinical specimen from which they were isolated.

Keywords: Pseudomonas aeruginosa; bacterial infections; burns; multi-drug resistance; wound infections.

MeSH terms

  • Acinetobacter baumannii*
  • Adult
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Bacteria
  • Bacterial Infections* / complications
  • Bacterial Infections* / drug therapy
  • Bacterial Infections* / epidemiology
  • Burns* / complications
  • COVID-19* / complications
  • Drug Resistance, Bacterial
  • Humans
  • Methicillin-Resistant Staphylococcus aureus*
  • Microbial Sensitivity Tests
  • Prospective Studies
  • Pseudomonas aeruginosa
  • Romania / epidemiology
  • Staphylococcal Infections* / drug therapy

Substances

  • Anti-Bacterial Agents

Grants and funding

This research received no external funding.