Glycaemic control and avenues for improvement among people with type 2 diabetes mellitus from rural Sri Lanka - a retrospective cohort study

Chamila Mettananda; Umesh Chathuranga; Tharanga Rathnayake; Nathasha Luke; Neranjala Meegodavidanage

doi:10.1016/j.lansea.2023.100169

Glycaemic control and avenues for improvement among people with type 2 diabetes mellitus from rural Sri Lanka - a retrospective cohort study

Lancet Reg Health Southeast Asia. 2023 Feb 27:12:100169. doi: 10.1016/j.lansea.2023.100169. eCollection 2023 May.

Authors

Chamila Mettananda¹, Umesh Chathuranga², Tharanga Rathnayake³, Nathasha Luke¹, Neranjala Meegodavidanage⁴

Affiliations

¹ Department of Pharmacology, Faculty of Medicine, University of Kelaniya - Ragama, Sri Lanka.
² South Asian Clinical Research (SACR), T.H. Anuradhapura, Sri Lanka.
³ Base Hospital, Medawachchiya, Sri Lanka.
⁴ Teaching Hospital, Anuradhapura, Sri Lanka.

Abstract

Background: The majority of Sri Lankans and South Asians are rural dwellers but follow-up data on glycaemic control and its associations in rural communities are sparse. We followed up a cohort of hospital-based rural Sri Lankans with diabetes from diagnosis up to 24-months.

Methods: We conducted a retrospective cohort study of people with type-2 diabetes (T2DM) diagnosed 24 months before enrolment who were being followed up at Medical/Endocrine clinics of five hospitals selected by stratified random sampling in Anuradhapura, a rural district of Sri Lanka from June 2018 to May 2019 and retrospectively followed them up to the diagnosis of the disease. Prescription practices, cardiovascular risk factor control and their correlates were studied using self-administered and interviewer-administered questionnaires and perusing medical records. Data were analysed using SPSS version-22.

Findings: A total of 421 participants [mean age 58.3 ± 10.4 years, female 340 (80.8%)] were included in the study. Most participants were started on anti-diabetic medications in addition to lifestyle measures. Of them, 270 (64.1%) admitted poor dietary-control, 254 (60.3%) inadequate medication-compliance and 227 (53.9%) physical inactivity. Glycaemic control was assessed mainly on fasting plasma glucose (FPG) and glycated haemoglobin (HbA1c) data were available in only 44 (10.4%). Target achievements in FPG, blood pressure, body mass index and non-smoking at 24-months following initiation of treatment were 231/421 (54.9%), 262/365 (71.7%), 74/421 (17.6%) and 396/421 (94.1%) respectively.

Interpretation: In this cohort of rural Sri Lankans with type-2 diabetes mellitus, all were started on anti-diabetic medications at the diagnosis, but glycaemic target achievement was inadequate at 24 months. We identified the major patient-related reasons for poor blood glucose control were poor compliance with diet/lifestyle and/or medications and misconceptions about antidiabetic medications.

Funding: None.

Keywords: Cohort study; Diabetes mellitus; Glycaemic-control; Rural; South-Asia; Sri Lanka.