Childhood Hypertrophic Cardiomyopathy Caused by Beta-Myosin Heavy Chain Variants Is Associated With a More Obstructive but Less Arrhythmogenic Phenotype Than Myosin-Binding Protein C Disease

Circ Genom Precis Med. 2023 Oct;16(5):483-485. doi: 10.1161/CIRCGEN.123.004118. Epub 2023 Jun 30.

Authors

Gabrielle Norrish^{1

2}, Vidthya Kadirrajah², Ella Field^{1

2}, Kathleen Dady¹, Jennifer Tollit^{1

2}, Karen McLeod³, Ruth McGowan⁴, Elena Cervi^{1

2}, Juan Pablo Kaski^{1

2}

Affiliations

¹ Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, United Kingdom (G.N., E.F., K.D., J.T., E.C., J.P.K.).
² Institute of Cardiovascular Science, University College London, United Kingdom (G.N., V.K., E.F., J.T., E.C., J.P.K.).
³ Department of Pediatric Cardiology, Royal Hospital for Children, Glasgow, United Kingdom (KML).
⁴ West of Scotland Centre for Genomic Medicine, Glasgow, United Kingdom (R.M.G.).

PMID: 37387224
DOI: 10.1161/CIRCGEN.123.004118

No abstract available

Keywords: cardiomyopathies; child; hypertrophy; myosin heavy chain; myosin-binding protein C; syncope.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cardiomyopathy, Hypertrophic* / genetics
Carrier Proteins / genetics
Child
Humans
Myosin Heavy Chains* / genetics
Phenotype

Substances

Myosin Heavy Chains
myosin-binding protein C
Carrier Proteins

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