Umbilical cord mesenchymal stem cell-derived exosomes promote axon regeneration during optic nerve injury through microRNA-dependent mTORC1 signalling

Clin Transl Med. 2023 Jul;13(7):e1319. doi: 10.1002/ctm2.1319.

Authors

Xuan Sang¹, Lei Tang¹, Liang Zhao², Nana Xu¹, Feng Liu¹, Yuhui Shen¹, Wei Wei³, Yaqi Cheng¹, Wanjing Huang¹, Yurun Liu¹, Yaru Su¹, Chao Xu³, Yongsheng Li³, Zhichong Wang¹, Sheng Liu¹

Affiliations

¹ State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
² Center for Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
³ Institute of experimental center, Guangdong Cord Blood Bank, Guangzhou, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Axons / physiology
Exosomes* / genetics
Humans
Mechanistic Target of Rapamycin Complex 1 / genetics
Mesenchymal Stem Cells*
MicroRNAs* / genetics
Nerve Regeneration / genetics
Optic Nerve Injuries* / genetics
Optic Nerve Injuries* / therapy
Umbilical Cord

Substances

MicroRNAs
Mechanistic Target of Rapamycin Complex 1