Associations between hearing loss and clinical outcomes: population-based cohort study

Marcello Tonelli; Natasha Wiebe; Meg Lunney; Maoliosa Donald; Tanis Howarth; Julie Evans; Scott W Klarenbach; David Nicholas; Tiffany Boulton; Stephanie Thompson; Kara Schick Makaroff; Braden Manns; Brenda Hemmelgarn

doi:10.1016/j.eclinm.2023.102068

Associations between hearing loss and clinical outcomes: population-based cohort study

EClinicalMedicine. 2023 Jun 29:61:102068. doi: 10.1016/j.eclinm.2023.102068. eCollection 2023 Jul.

Affiliations

¹ Department of Medicine, University of Calgary, Calgary, Canada.
² Department of Medicine, University of Alberta, Edmonton, Canada.
³ Alberta Health Services, Calgary, Canada.
⁴ Alberta Health Services, Kitscoty, Canada.
⁵ Faculty of Social Work, University of Calgary, Calgary, Canada.
⁶ Department of Community Health Sciences, University of Calgary, Canada.
⁷ Faculty of Nursing, University of Alberta, Edmonton, Canada.

Abstract

Background: Hearing loss (HL) is a leading cause of disability worldwide, but its clinical consequences and population burden have been incompletely studied.

Methods: We did a retrospective population-based cohort study of 4,724,646 adults residing in Alberta between April 1, 2004 and March 31, 2019, of whom 152,766 (3.2%) had HL identified using administrative health data. We used administrative data to identify comorbidity and clinical outcomes, including death, myocardial infarction, stroke/transient ischemic attack, depression, dementia, placement in long-term care (LTC), hospitalization, emergency visits, pressure ulcers, adverse drug events and falls. We used Weibull survival models (binary outcomes) and negative binomial models (rate outcomes) to compare the likelihood of outcomes in those with vs without HL. We calculated population-attributable fractions to estimate the number of binary outcomes associated with HL.

Findings: The age-sex-standardized prevalence of all 31 comorbidities at baseline was higher among participants with HL than those without. Over median follow-up of 14.4 y and after adjustment for potential confounders at baseline, participants with HL had higher rates of days in hospital (rate ratio 1.65, 95% CI 1.39, 1.97), falls (RR 1.72, 95% CI 1.59, 1.86), adverse drug events (RR 1.40, 95% CI 1.35, 1.45), and emergency visits (RR 1.21, 95% CI 1.14, 1.28) compared to those without, and higher adjusted hazards of death, myocardial infarction, stroke/transient ischemic attack, depression, heart failure, dementia, pressure ulcers and LTC placement. The estimated number of people with HL who required new LTC placement annually in Canada was 15,631, of which 1023 were attributable to HL. Corresponding estimates for new dementia among people with HL were 14,959 and 4350, and for stroke/TIA the estimates were 11,582 and 2242.

Interpretation: HL is common, is often accompanied by substantial comorbidity, and is associated with significant increases in risk for a broad range of adverse clinical outcomes, some of which are potentially preventable. This high population health burden suggests that increased and coordinated investment is needed to improve the care of people with HL.

Funding: Canadian Institutes of Health Research; David Freeze chair in health services research.

Keywords: Epidemiology; Hearing loss.