Reaction time in psychomotor vigilance task is related to hypoxic load in males with sleep apnea

Purbanka Pahari; Henri Korkalainen; Tuomas Karhu; Erna Sif Arnardottir; Juha Töyräs; Timo Leppänen; Sami Nikkonen

doi:10.1111/jsr.13988

Reaction time in psychomotor vigilance task is related to hypoxic load in males with sleep apnea

J Sleep Res. 2024 Apr;33(2):e13988. doi: 10.1111/jsr.13988. Epub 2023 Jul 13.

Authors

Purbanka Pahari^{1

2}, Henri Korkalainen^{1

2}, Tuomas Karhu^{1

2}, Erna Sif Arnardottir^{3

4}, Juha Töyräs^{1

5

6}, Timo Leppänen^{1

2

5}, Sami Nikkonen^{1

2}

Affiliations

¹ Department of Technical Physics, University of Eastern Finland, Kuopio, Finland.
² Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland.
³ Reykjavik University Sleep Institute, School of Technology, Reykjavik University, Reykjavik, Iceland.
⁴ Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland.
⁵ School of Electrical Engineering and Computer Science, The University of Queensland, Brisbane, Queensland, Australia.
⁶ Science Service Center, Kuopio University Hospital, Kuopio, Finland.

PMID: 37448111
DOI: 10.1111/jsr.13988

Abstract

Oxygen saturation (SpO₂ )-based parameters are more strongly linked to impaired daytime vigilance than the conventional diagnostic metrics in patients with obstructive sleep apnea (OSA). However, whether the association between SpO₂ -based parameters and impaired daytime vigilance is modulated by sex, remains unknown. Hence, we investigated the interplay between sex and detailed SpO₂ -based metrics and their association with impaired vigilance in patients with OSA. The study population consisted of 855 (473 males, 382 females) patients with suspected OSA who underwent overnight polysomnography and psychomotor vigilance task (PVT). The population was grouped by sex and divided into quartiles (Q1-Q4) based on median reaction times (RTs) in the PVT. In addition to conventional diagnostic metrics, desaturation severity (DesSev), fall severity (FallSev), and recovery severity (RecovSev) were compared between the sexes and between the best (Q1) and worst (Q4) performing quartiles by using cumulative distribution functions (CDFs). Additionally, sex-specific covariate-adjusted linear regression models were used to investigate the connection between the parameters and RTs. The CDFs showed significantly higher hypoxic load in Q4 in males compared to females. In addition, the DesSev (β = 8.05, p < 0.01), FallSev (β = 6.48, p = 0.02), RecovSev (β = 9.13, p < 0.01), and Oxygen Desaturation Index (β = 12.29, p < 0.01) were associated with increased RTs only in males. Conversely, the Arousal Index (β = 10.75-11.04, p < 0.01) was associated with impaired vigilance in females. The severity of intermittent hypoxaemia was strongly associated with longer RTs in males whereas the Arousal Index had the strongest association in females. Thus, the impact of hypoxic load on impaired vigilance seems to be stronger in males than females.

Keywords: fall severity; hypoxic load; impaired vigilance; intermittent hypoxemia; recovery severity; sex difference.

MeSH terms

Female
Humans
Hypoxia / complications
Male
Reaction Time
Severity of Illness Index
Sleep Apnea Syndromes* / complications
Sleep Apnea, Obstructive* / complications

Abstract

MeSH terms

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