Nanomaterial-based biosensors for avian influenza virus: A new way forward

Wesley Wei-Wen Hsiao; Gianna Fadhilah; Cheng-Chung Lee; Ryu Endo; Yu-Jou Lin; Stefanny Angela; Chia-Chi Ku; Huan-Cheng Chang; Wei-Hung Chiang

doi:10.1016/j.talanta.2023.124892

Nanomaterial-based biosensors for avian influenza virus: A new way forward

Talanta. 2023 Dec 1:265:124892. doi: 10.1016/j.talanta.2023.124892. Epub 2023 Jul 5.

Authors

Wesley Wei-Wen Hsiao¹, Gianna Fadhilah², Cheng-Chung Lee³, Ryu Endo⁴, Yu-Jou Lin², Stefanny Angela², Chia-Chi Ku⁵, Huan-Cheng Chang⁶, Wei-Hung Chiang⁷

Affiliations

¹ Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, 10607, Taiwan. Electronic address: weshsiao@mail.ntust.edu.tw.
² Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, 10607, Taiwan.
³ The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan.
⁴ Department of Biomedical Engineering, The Ohio State University, 43210, USA.
⁵ Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan.
⁶ Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, 10607, Taiwan; Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, 106319, Taiwan.
⁷ Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, 10607, Taiwan. Electronic address: whchiang@mail.ntust.edu.tw.

PMID: 37451119
DOI: 10.1016/j.talanta.2023.124892

Abstract

Avian influenza virus (AIV) is a zoonotic virus that can be transmitted from animals to humans. Although human infections are rare, the virus has a high mortality rate when contracted. Appropriate detection methods are thus crucial for combatting this pathogen. There is a growing demand for rapid, selective, and accurate methods of identifying the virus. Numerous biosensors have been designed and commercialized to detect AIV. However, they all have considerable shortcomings. Nanotechnology offers a new way forward. Nanomaterials produce more eco-friendly, rapid, and portable diagnostic systems. They also exhibit high sensitivity and selectivity while achieving a low detection limit (LOD). This paper reviews state-of-the-art nanomaterial-based biosensors for AIV detection, such as those composed of quantum dots, gold, silver, carbon, silica, nanodiamond, and other nanoparticles. It also offers insight into potential trial protocols for creating more effective methods of identifying AIV and discusses key issues associated with developing nanomaterial-based biosensors.

Keywords: Avian influenza virus; Biomarker; Biosensor; Nanomaterial; Point-of-care testing.

Publication types

Review

MeSH terms

Animals
Biosensing Techniques* / methods
Humans
Influenza A virus*
Influenza in Birds* / diagnosis
Nanoparticles*
Nanostructures*