A Case of Overlap Syndrome of Systemic Sclerosis and Cryoglobulinemic Vasculitis With Central Nervous System Involvement

Youjin Jung; Eunyoung Emily Lee; Jina Yeo; Mi Hyeon Kim; Se Rim Choi; Yeong Wook Song

doi:10.4078/jrd.2021.28.4.242

A Case of Overlap Syndrome of Systemic Sclerosis and Cryoglobulinemic Vasculitis With Central Nervous System Involvement

J Rheum Dis. 2021 Oct 1;28(4):242-246. doi: 10.4078/jrd.2021.28.4.242.

Authors

Youjin Jung¹, Eunyoung Emily Lee², Jina Yeo¹, Mi Hyeon Kim¹, Se Rim Choi¹, Yeong Wook Song¹

Affiliations

¹ Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
² Division of Rheumatology, Department of Internal Medicine, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu, Korea.

Abstract

Mixed cryoglobulinemic vasculitis (CV) is occasionally caused by autoimmune diseases including systemic sclerosis. Multiorgan involvement such as skin, kidney, and peripheral nerve involvement is common in mixed CV. However, central nervous system (CNS) involvement is extremely rare. Here, we report a case of overlap syndrome of limited cutaneous systemic sclerosis and mixed cryoglobulinemic vasculitis with CNS involvement. The neurologic deficits and systemic symptoms improved promptly after steroid and cyclophosphamide therapy.

Keywords: Central nervous system; Cryoglobulinemia; Scleroderma; Vasculitis; systemic.

Publication types

Case Reports