Cardiovascular and pulmonary activity of platelet-activating factor (PAF-acether) and its derivatives

F Berti; V Ferri; M Pallavicini; M Pretolani; E Tremoli; E Valoti; L Villa

doi:10.1016/0031-6989(86)90150-5

Cardiovascular and pulmonary activity of platelet-activating factor (PAF-acether) and its derivatives

Pharmacol Res Commun. 1986 Jun;18(6):557-62. doi: 10.1016/0031-6989(86)90150-5.

Authors

F Berti, V Ferri, M Pallavicini, M Pretolani, E Tremoli, E Valoti, L Villa

PMID: 3749244
DOI: 10.1016/0031-6989(86)90150-5

Abstract

Stereoselective synthesis and biological properties of PAF-acether, its enantiomer and some analogues of both are reported. The results clearly indicate that the ONIUM SIZE and SHAPE of the various compounds tested are important in determining guinea-pig bronchoconstriction and human platelet aggregation.

MeSH terms

Airway Resistance / drug effects
Animals
Blood Pressure / drug effects
Guinea Pigs
Hemodynamics / drug effects*
Lung / drug effects*
Male
Molecular Conformation
Platelet Activating Factor / analogs & derivatives*
Platelet Activating Factor / pharmacology
Platelet Aggregation / drug effects
Stereoisomerism

Substances

Platelet Activating Factor