Ophthalmic complications during the dengue epidemic in Reunion Island in 2020: a case series and review of the literature

BMC Infect Dis. 2023 Aug 2;23(1):506. doi: 10.1186/s12879-023-08432-4.

Abstract

Introduction: Dengue is an arboviral disease transmitted by the dengue virus, whose vectors are Aedes aegypti and Aedes albopictus. The acute phase with its cohort of well-known symptoms is usually spontaneously favorable. Since 2020 in Reunion Island, a new symptom has appeared: the ocular damage of dengue fever, which has already been described in South Asia and South-East Asia. We therefore decided to describe the clinical, biological, ophthalmological, therapeutic, and outcomes of patients with ocular manifestations during dengue fever in Reunion Island in 2020.

Patients and methods: This was a retrospective observational study. Patients were included from January 2020 to August 2020 and then reassessed by teleconsultation 1 year later. The patients were identified from the French public health surveillance network by all ophthalmologists on the island. Medical data were collected directly from medical records.

Results: Twenty-eight patients were included. The mean age was 41.9 years. Ocular involvement occurred approximately 9.2 days after the onset of dengue symptoms. The main symptoms were scotoma (71.4%) and sudden decrease of visual acuity (39.2%). Eighteen patients (64.2%) had macular involvement. Fourteen patients were treated with oral or intravenous corticosteroids. Twenty-two (78.5%) patients were evaluated by telephone one year later. Scotoma and decreased visual acuity persisted in 15 patients. Thirteen patients (59%) were bothered by night driving, 32% of patients had reading difficulties and 27% of patients became sensitive to prolonged exposure to screens.

Conclusion: Ocular complications of dengue require early and collegial management to limit the risk of long-term sequelae. Further studies on the characteristics and complications of dengue fever are needed to better understand this disease.

Keywords: Dengue; Maculopathy; Reunion island; Scotoma.

Publication types

  • Review

MeSH terms

  • Adult
  • Aedes*
  • Animals
  • Dengue Virus*
  • Dengue* / complications
  • Dengue* / epidemiology
  • Humans
  • Mosquito Vectors
  • Observational Studies as Topic
  • Reunion / epidemiology
  • Scotoma