Probiotic-related Clostridium butyricum bacteremia: a case report and literature review

Kazuhiro Ishikawa; Ryo Hasegawa; Koko Shibutani; Yumiko Mikami; Fujimi Kawai; Takahiro Matsuo; Yuki Uehara; Nobuyoshi Mori

doi:10.1016/j.anaerobe.2023.102770

Probiotic-related Clostridium butyricum bacteremia: a case report and literature review

Anaerobe. 2023 Oct:83:102770. doi: 10.1016/j.anaerobe.2023.102770. Epub 2023 Aug 5.

Authors

Kazuhiro Ishikawa¹, Ryo Hasegawa², Koko Shibutani³, Yumiko Mikami⁴, Fujimi Kawai⁵, Takahiro Matsuo⁶, Yuki Uehara⁷, Nobuyoshi Mori³

Affiliations

¹ Department of Infectious Diseases, St. Luke's International Hospital, Tokyo, Japan. Electronic address: ishikawakazuhiro@gmail.com.
² Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.
³ Department of Infectious Diseases, St. Luke's International Hospital, Tokyo, Japan.
⁴ Department of Clinical Laboratory, St. Luke's International Hospital, Tokyo, Japan.
⁵ Library, Center for Academic Resources, St. Luke's International University, Japan.
⁶ Department of Infectious Diseases, St. Luke's International Hospital, Tokyo, Japan; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁷ Department of Infectious Diseases, St. Luke's International Hospital, Tokyo, Japan; Department of Infectious Diseases, Fujita Health University School of Medicine, Aichi, Japan.

PMID: 37544356
DOI: 10.1016/j.anaerobe.2023.102770

Abstract

We report three cases of Clostridium butyricum bacteremia associated with taking C. butyricum-related probiotics. We performed a literature review and found 11 cases of C. butyricum bacteremia including our cases. Nine cases related to probiotics. We should consider that probiotics may infect clinically unstable patients.

Keywords: Clostridium butyricum; Probiotic-associated bacteremia.

Publication types

Review
Case Reports

MeSH terms

Bacteremia* / diagnosis
Clostridium butyricum*
Humans
Probiotics*