What does not look like celiac disease and instead it is

Vincenzo Villanacci; Rachele Del Sordo; Orsola Setti; Barbara Zanini; Giovanni Casella

doi:10.22037/ghfbb.v16i1.2686

What does not look like celiac disease and instead it is

Gastroenterol Hepatol Bed Bench. 2023;16(2):230-233. doi: 10.22037/ghfbb.v16i1.2686.

Authors

Vincenzo Villanacci¹, Rachele Del Sordo², Orsola Setti¹, Barbara Zanini^{2

3}, Giovanni Casella^{2

4}

Affiliations

¹ Institute of Pathology ASST-Spedali Civili University of Brescia, Brescia, Italy.
² Department of Medicine and Surgery, Section of Anatomic Pathology and Histology, Medical School, University of Perugia, Perugia, Italy.
³ Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
⁴ Medical Department, Desio Hospital, 20832 Desio, Italy.

Abstract

The celiac disease (CD) diagnosis sometimes is challenging and diagnostic process cannot always follow a simple algorithm but it requires a close collaboration between histo-pathologists, clinicians, laboratory and genetic experts. The genetic predisposition for CD is related to HLA-DQ2 and/or DQ8 but other HLA haplotypes and non-HLA genes may be involved in genetic predisposition. In particular DQ7 may represent an additive and independent CD risk associated haplotype. We describe an unusual case of a female 42 year old with a previous diagnosis of Hodgkin lymphoma, who has a clinical presentation suggestive for CD with negativity for anti-transglutaminase and anti-endomysium antibodies and HLA-DQ7 positivity.

Keywords: Celiac disease; Gluten free diet.; HLA-DQ7.

Publication types

Case Reports