Clostridium ventriculi in a cynomolgus monkey with acute gastric dilatation and rupture: A case report

J Med Primatol. 2024 Feb;53(1):e12668. doi: 10.1111/jmp.12668. Epub 2023 Aug 15.

Abstract

Acute gastric dilatation (AGD) is one of the most prevalent and life-threatening diseases in nonhuman primates worldwide. However, the etiology of this syndrome has not been determined. Recently, sudden death occurred in a 7-year-old female cynomolgus monkey with a history of fecal microbiota transplantation using diarrheic stools. The monkey had undergone surgery previously. On necropsy, gastric dilatation and rupture demonstrated a tetrad arrangement on histopathologic examination. On 16S rRNA sequencing, a high population of Clostridium ventriculi was identified in the duodenum adjacent to stomach but not in the colon. This paper is the first report of Clostridium ventriculi infection in a cynomolgus macaque with acute gastric dilatation and rupture.

Keywords: Clostridium ventriculi; acute gastric dilatation and rupture; cynomolgus monkey; microbiome.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Clostridium*
  • Female
  • Gastric Dilatation* / pathology
  • Gastric Dilatation* / veterinary
  • Macaca fascicularis
  • RNA, Ribosomal, 16S

Substances

  • RNA, Ribosomal, 16S

Supplementary concepts

  • Clostridium ventriculi