Antidiabetic Effect of Star Anise (Illicium verum) in Streptozotocin-induced Diabetic Rats

Cardiovasc Hematol Disord Drug Targets. 2023;23(2):92-98. doi: 10.2174/1871529X23666230823112113.

Abstract

Aim: The current study aimed to evaluate the antidiabetic potential of Illicium verum fruits.

Background: Illicium verum fruits are frequently used by the Moroccan population in the treatment of diabetes.

Methods: The antihyperglycemic effect of the aqueous extract of Illicium verum fruits (AEIVF) in rats was assessed. The effects of AEIVF (20 mg/kg) on glycemia and lipid profile as well as its phytochemical and antioxidant properties were evaluated.

Results: In normal and diabetic rats, AEIVF reduced blood glucose levels 6 hours after administration. Furthermore, after 7 days of treatment, glycemia was lowered in diabetic rats, and this extract exhibited an antioxidant activity.

Conclusion: The study shows that Illicium verum possesses a potent antidiabetic activity. In addition, the toxicity of AEIVF was evaluated and the LD50 value was found to be greater than the 2 g/kg dose.

Keywords: Illicium verum; antidiabetic; antioxidant activity; oral glucose test tolerance; phytochemical; streptozotocin; toxicity..

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Diabetes Mellitus, Experimental* / drug therapy
  • Hypoglycemic Agents / pharmacology
  • Hypoglycemic Agents / therapeutic use
  • Illicium* / chemistry
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Rats
  • Streptozocin

Substances

  • Streptozocin
  • Hypoglycemic Agents
  • Plant Extracts
  • Antioxidants